In the former case, the disease may go by the name of "pituitary gland adenoma," a nod to the benign type of tumor most commonly responsible for Cushings or as adrenal gland hyperplasia by way of describing the brain tumor's effect on the pituitary. With Cushing's disease, dogs' adrenal glands will produce too much cortisol either 1) because of a tumor located in the brain's pituitary gland (which stimulates the adrenal gland's cortisol-producing tissue) or, 2) less commonly, because of a tumor in the adrenal gland itself. Hyperadrenocorticism or Cushing's disease, also known as Cushing's syndrome, is a common endocrine disease of middle-aged dogs responsible for a wide variety of symptoms associated with increased secretion of the hormone cortisol from the adrenal glands.
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